Unai Emery seeks to turn Villa Park into a fortress once more as Aston Villa face Fenerbahce in the UEFA Champions League, with Leon Goretzka making his squad return.
Manuel Pellegrini's high-flying Betis seek another European victory as Francesco Farioli's Benfica target their first Champions League points of the campaign at Estadio Benito Villamarin.
Norwegian side Viking FK faces a monumental challenge as German giants Bayern Munich visit Lyse Arena in Round 2 of the UEFA Champions League.
Both sides seek to build on opening-day victories as Lens welcome unbeaten Sporting CP to Stade Bollaert-Delelis.
In-form Sporting CP welcome Turkish champions Galatasaray to the Estádio José Alvalade for an explosive opening fixture.
Hansi Flick's high-flying Catalans look to extend their perfect domestic momentum against Giovanni van Bronckhorst's Feyenoord.
Arsenal travel to Naples riding a four-game winning streak in domestic competition, while Napoli seek redemption after back-to-back Serie A defeats.
A breakdown of recent form, squad availability, key player matchups, and predictions ahead of Liverpool vs. Atletico Madrid at Anfield.
Aston Villa open their UEFA Champions League campaign away at Jan Breydel Stadion against Belgian champions Club Brugge.
An in-depth pre-match analysis of form, key player matchups, confirmed lineups, and predictions ahead of the Champions League opener.
Real Madrid look to rebound from a domestic stumble while Inter aim to break a decades-long winless streak at the Santiago Bernabéu.
