Unai Emery seeks to turn Villa Park into a fortress once more as Aston Villa face Fenerbahce in the UEFA Champions League, with Leon Goretzka making his squad return.
Manuel Pellegrini's high-flying Betis seek another European victory as Francesco Farioli's Benfica target their first Champions League points of the campaign at Estadio Benito Villamarin.
Norwegian side Viking FK faces a monumental challenge as German giants Bayern Munich visit Lyse Arena in Round 2 of the UEFA Champions League.
Both sides seek to build on opening-day victories as Lens welcome unbeaten Sporting CP to Stade Bollaert-Delelis.
Bournemouth embark on their first-ever European match against Pellegrino Matarazzo's Real Sociedad in the Europa League league stage.
Juventus look to bounce back from domestic disappointment against Europa League newcomers NEC Nijmegen at Allianz Stadium.
In-form Black Eagles aim to maintain perfect home record as out-of-sorts French side visit Istanbul.
Martin O'Neill's side look to bounce back at Celtic Park as Hungarian champions Ferencvaros arrive for their Europa League opener.
Unbeaten Elversberg face reigning champions Bayern Munich at the Ursapharm-Arena an der Kaiserlinde in Matchweek 3.
Roberto De Zerbi's Tottenham search for their first Premier League goal and win of the season as David Moyes brings an unbeaten Everton side to London.
Aston Villa search for their opening league goal and win of the campaign against a stubborn Nottingham Forest side.
In-form Sporting CP welcome Turkish champions Galatasaray to the Estádio José Alvalade for an explosive opening fixture.